Greek organizations for men have been part of the Presbyterian College community since 1890 and for women since 1989. PC has a total of six national fraternity chapters on campus. These are North-American Interfraternity Conference organizations: Alpha Sigma Phi, Kappa Alpha, Pi Kappa Alpha, Pi Kappa Phi, Sigma Nu, and Theta Chi.

Approximately 43 percent of the male student body is part of a fraternity. PC has three National Panhellenic Conference sororities: Alpha Delta Pi, Sigma Sigma Sigma and Zeta Tau Alpha.

Approximately 38 percent of females on campus are members of a sorority.

Male and female Greek recruitment is under the careful regulation of the college Office of Student Activities & Greek Life, the Interfraternity Council and the Panhellenic Council. Recruitment takes place in the fall. Fraternity potential new members must have a "C" average to qualify for full membership. Each sorority has specific G.P.A. requirements for membership. Presbyterian College also has a chapter of the Order of Omega National Greek Honor Society that recognizes Greek members who display outstanding commitments to scholarship and service.