Assistant Professor of Chemistry
2002-07 NIH Postdoctoral Fellow, Drexel University College of Medicine, Philadelphia, PA
2002 Ph.D. Drexel University College of Medicine, Philadelphia, PA
1997 B.S. Rider University, Lawrenceville, NJ
Dr. Swain’s research interest is in utilizing the yeast Saccharomyces cerevisiae as a model system to study type 2 diabetes. Specifically, the focus is on how the loss of endocytic function results in aberrant glucose homeostasis through the deregulation of glucose transporter localization/function. Data shows that the BAR domain protein Rvs161 is required for proper transporter localization and function. Recent reviews describe BAR domain containing proteins as curvature inducing/stabilizing proteins essential for affecting a wide variety of membrane remodeling processes, including endocytosis. Endocytosis and degradation of transporters is critically important in maintaining glucose homeostasis in yeast as well as mammals. Yeast also share similar components of glucose signaling and glucose transporter pathways with mammalian counterparts, making yeast a useful model system for studies of glucose transporter biology. Yeast strains lacking the RVS161 gene fail to grow under conditions of glucose limitation and harbor endocytosis defects. Recent data indicates that overexpression of specific glucose transporters can suppress this defect. Additionally, data suggests that glucose transporter interactions are required for proper transporter function.
Presbyterian College, Clinton, SC
2013-Present, Assistant Professor of Chemistry-Tenure track
2014-Present, Director Biochemistry Program
2014-Present, Advisor American Chemical Society Student Affiliate
Newberry College, Newberry, SC
2007-2013, Associate Professor of Chemistry-Tenured
2010-2013, Founder/Director SMART, Summer Mentoring And Research Training Program
2009-2013, Co-Founder/Advisor Future Medical Professional Association
Mercer County Community College, Trenton, NJ
2005-2007, Assistant Adjunct Professor of Biology
Current Courses Taught
General Chemistry II, CHEM102, laboratory & lecture
Biochemistry I & II, BCHE 307/308, laboratory & lecture
Introduction to Research, CHEM 380
Honors Research, CHEM 398
Research Experience, CHEM 440
Directed Studies, CHEM 442
Launching Vocation, Leadership & Service, COLS 2000
- Glucose Transporter Homeostasis in Saccharoymces cerevisiae, Manuscript in Preparation
- Morgan, J., McCourt P., Rankin L., Swain, E., Rice L., Nickels, J.T. Jr. Altering sphingolipid metabolism in cells lacking the yeast amphiphysin ortholog, Rvs161, reinitiates sugar transporter endocytosis. Eukaryot Cell.2009 May;8(5):779-89
- Loll, P.J. Swain, E. Chen, Y., Turner, B.T., Zhang, J.F., Structure of the SH3 domain of rat endophilin A2. Acta Cryst.(2008) F64, 243-246
- Germann, M., Swain, E., Bergman, L., Nickels, J.T. Jr. Characterizing the sphingolipid signaling pathway that remediates defects associated with loss of the yeast amphiphysin-like orthologs, Rvs161p and Rvs167p. J. Biol. Chem. (2005); 280: 4270-8.
- Swain, E., Baudry, K., Germann, M., Allegood, J., Merrill, A., Nickels, J.T. Jr. Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by Human ARV1. J. Biol. Chem. (2002); 277: 36152-60.
- Swain, E., Baudry, K., Germann, M., Allegood, J., Merrill, A., Nickels, J.T. Jr. Sterol Dependent Regulation of Sphingolipid Biosynthesis in Saccharomyces cerevisiae. J. Biol. Chem. (2002); 277: 26177-84.
- Baudry, K., Swain, E., Rahier, A., Germann, M., Batta, A., Rondet, S., Mandala, S., Henry, K., Tint, G.S., Edlind, T., Kurtz, M., Nickels, J.T. Jr. The Effect of the erg26-1 Mutation on the Regulation of Lipid Metabolism in Saccharomyces cerevisiae. J. Biol. Chem. (2001); 276: 12702-11.